Seems Like Microbicides Had A Bad Day
Word has quickly spread that (another) Phase III microbicide candidate has been taken off the shelf. Cellulose sulfate, an attachment inhibitor, may have been causing increased risk for HIV transmission in trials being done at several sites. As a result, these trials have been halted.
This news follows the closure of another phase III trial in August 2006. As Keith Alcorn wrote yesterday, that trial was showing “a lower than expected rate of HIV infections”. Though this is a less controversial reason for trial closure, both were cellulose sulfate and showed promise as contraceptive gels.
This is quite disheartening news for those of us working diligently to make microbicides a reality for the millions of women and men at risk for HIV through unprotected sex. Microbicides, a topical gel that could be used inside the vagina or anus during intercourse to reduce the likelihood of HIV transmission and possibly other STDs, would provide a non-barrier risk prevention option to the rather slim arsenal of HIV prevention options that currently exists.
Advocacy will now focus on the three products (all are not cellulose sulfate based) still in Phase III development, one of which is nearing completion and expected to have results by the end of this year. In the meantime, the microbicide advocacy community will continue to call for the necessary funding and support to meet the highest standards in HIV clinical trials and to put forth a greater inventory of promising candidate products.






